Triple G SC injection with E-Visit STRIKER PHARMACY

THIS ITEM REQUIRES A PRESCRIPTION FROM DR.K. NEW PATIENTS MUST PAY THE $99.99 NEW PATIENT FEE AND FILL OUT THE NEW PATIENT FORMS BEFORE ORDERING ANYTHING ON THIS SITE. DO NOT SUBMIT A FORM UNLESS YOU ARE ALREADY A PATIENT WITH A PUSH HEALTH ACCOUNT.

**Because this is a new medication to the market, there are restrictions on who may order this medication. You MUST ALSO receive special permission to order this specific medication prior to placing your FIRST order. You must also fill out your Triple G initial request and consent form. You can click here to access the form. Please message us on your Push Health account to request permission after you have reviewed the qualification guidelines and have filled out the form.

**After you initially receive permission, you may simply return here to order your next doses (you do not need to ask permission).

***THIS ITEM CURRENTLY SHIPS TO ALL MY PATIENTS***

1. This medication will be shipped to you from STRIKER PHARMACY. Striker Pharmacy ships to all of my states.
2. Injection supplies are included.
3. The current shipping time is around 7-10 days, but often ships much sooner.
4. It will arrive to you cool and will need to be kept in the refrigerator.
5. Each vial contains 4 weeks of either the 1mg, 2mg, 4mg, 8mg, or 12mg dose of Triple G in 2ml of fluid (200 units total).
6. Your injection dose with these vials is ALWAYS 0.5ml (50 units), no matter your dose for that week.
7. You MUST order the dosage you intend to take, as these vials are designed to be used for 4-5 weeks only. We will be very strict on this and will carefully monitor your ordering practices. To be successful, you should order every 3-4 weeks to make sure you don't miss any doses.
8. You may order ONE VIAL at a time.

VIAL CONCENTRATIONS

• 1mg Dose: Retatrutide 1mg/0.5ml (2ml vial): $300
• 2mg Dose: Retatrutide 2mg/0.5ml (2ml vial): $400
• 4mg Dose: Retatrutide 4mg/0.5ml (2ml vial): $500
• 8mg Dose: Retatrutide 8mg/0.5ml (2ml vial): $575
• 12mg Dose: Retatrutide 12mg/0.5ml (2ml vial): $675

*Note that with the first vial, the concentration is retatrutide 1mg/0.5ml of medication. You can see above that as you move up in dosage, the amount of retatrutide in each 0.5ml (50 units) increases to match that dose. Each vial has a total of 2ml (200 units) so your dose is always 50 units. DO NOT INCREASE THE NUMBER OF UNITS YOU INJECT WHEN YOU MOVE UP FROM ONE DOSE TO THE NEXT.

DOSING

The standard dose with these vials is always 50units SC once a week, no matter the dose. The higher the dose, the higher the concentration of medication in those 50 units. As described below, some patients may want to inject a half dose (25 units) their first two weeks, then the full dose for 3 weeks with your first order.

Patients should discard their vial after the 4th or 5th puncture and should generally use each vial within 5-6 weeks after first puncture.

WHAT IS THE TRIPLE G INJECTION?

If you keep up with the “latest and greatest” weight loss medications, you have probably heard of the revolutionary new drug currently in phase 3 of clinical trials on the path to FDA approval for treating obesity (called retatrutide or LY3437943 in the studies).We refer to it as the “Triple G” drug because of its action on three different receptors in your body that leads to weight loss: GLP-1, GIP, and GCG receptors.

• GLP-1 (glucagon-like peptide-1) receptor agonists: Medications such as Saxenda (liraglutide) and Ozempic (semaglutide) were the first of these types of medications. Wegovy (semaglutide) is FDA-approved for weight loss. Compounded semaglutide would fall in this category as well.
• GLP-1 PLUS GIP (glucose-dependents insulinotropic polypeptide) receptor agonists: When Mounjaro (tirzepatide) was introduced in 2022, it was clear that it’s dual-action properties lead to superior weight loss in studies. Zepbound (tirzepatide), released in November 2023, is the FDA-approved version of Mounjaro. Compounded tirzepatide would fall in this category as well,
• GLP-1 PLUS GIP PLUS GCG (glucagon) receptor agonists: This brand-new medication is a “Triple G” in that it acts on three different receptors. This can have additional benefits on appetite control and fat burning.

While Triple G has quickly emerged as an exciting new weight-loss medication, it is important to know that it is NOT an FDA-approved medication yet. Phase 2 trials have been completed, however, and the results have been nothing but amazing. The study, published in the New England Journal of Medicine (NEJM), included 338 adults with obesity or overweight.

• After 24 weeks, the people who received 12 milligrams of retatrutide—the highest dosage—saw up to 17.5% weight loss. After 48 weeks, the group saw 24.2% average weight loss.
• Every patient that received the highest dose (12mg) lost at least 5% of their body weight and about 1 in 4 patients lost 30% or more of their body weight!
• Participants lost an average of about 60 pounds over an 11-month period.
• Also, by the end of the study, the research suggested that participants hadn’t reached their weight plateau yet. That could mean even more weight loss might be possible when using retatrutide over a longer period.
• Although it has not been tested head-to-head against semaglutide or tirzepatide, weight loss in the trial seemed to happen quicker than other weight loss medications. In its initial studies, semaglutide on average reduced body weight by around 15%, or about 34 pounds, after 68 weeks. Tirzepatide was shown to reduce body weight, by 22.5% on average, or about 52 pounds, after 72 weeks.
• These early studies indicate that retatrutide has a similar side effect and safety profile as tirzepatide and semaglutide.
  
  

Retatrutide Availability

As mentioned above, retatrutide is still undergoing clinical trials before it can be FDA-approved. It is currently in phase 3, but it still could be a few years before it is available commercially as a brand name medication. This means that it will be a while before you can pick this up at your local pharmacy (like Wegovy or Zepbound).

However, some compounding pharmacies are now offering compounded retatrutide. They are able to source this Triple G peptide from the same reputable sources where they obtain semaglutide and tirzepatide. I am now able to provide this medication to select patients.

• If you have never been on tirzepatide or semaglutide, you would start at the 1mg starter dose for 4 weeks. I’d prefer you to use tirzepatide first, but I will allow those with higher BMIs as above to start with Triple G or switch earlier than those with lower BMIs.
  
  
• If you are currently on tirzepatide and would like to switch to Triple G:
  
  
  • If you have recently completed the 2.5mg dose of tirzepatide and feel it is not effective, order the 2mg dose of Triple G. When first switching over, you may inject 1mg the first 1-2 weeks to assess your tolerance and prevent side effects. The vial would last you 5 weeks in this case. Instead of 50 units, you would simply inject 25 units for the first two weeks.
  • If you have recently completed the 5mg dose of tirzepatide and feel it is not effective, order the 4mg dose of Triple G.When first switching over, you may inject 2mg the first 1-2 weeks to assess your tolerance and prevent side effects. The vial would last you 5 weeks in this case. Instead of 50 units, you would simply inject 25 units for the first two weeks.
  • If you have recently completed the 10mg dose or higher of tirzepatide and feel it is not effective, order the 12mg dose of Triple G.When first switching over, you may inject 6mg the first 1-2 weeks to assess your tolerance and prevent side effects. The vial would last you 5 weeks in this case. Instead of 50 units, you would simply inject 25 units for the first two weeks.
    
    
• If you are currently on semaglutide:
  
  
  • Patients are encouraged to order a trial period of tirzepatide before ordering Triple G. Only patients in category one will be allowed to order Triple G prior to a trial period of tirzepatide.
  • If you have recently completed the 0.25mg dose of semaglutide and feel it is not effective, order the starter 1mg dose of Triple G.
  • If you have recently completed the 0.5mg dose of semaglutide and feel it is not effective, order the 2mg dose of Triple G. When first switching over, you may inject 1mg the first 1-2 weeks to assess your tolerance and prevent side effects. The vial would last you 5 weeks in this case. Instead of 50 units, you would simply inject 25 units for the first two weeks.
  • If you have recently completed the 1mg dose of semaglutide and feel it is not effective, order the 4mg dose of Triple G. When first switching over, you may inject 2mg the first 1-2 weeks to assess your tolerance and prevent side effects. The vial would last you 5 weeks in this case. Instead of 50 units, you would simply inject 25 units for the first two weeks.
  • If you have recently completed the 1.7mg or 2.4/2.5mg dose of semaglutide and feel it is not effective, order the 8mg dose of Triple G. When first switching over, you may inject 4mg the first 1-2 weeks to assess your tolerance and prevent side effects. The vial would last you 5 weeks in this case. Instead of 50 units, you would simply inject 25 units for the first two weeks.
    
    YOU MAY ALSO START AT A LOWER DOSE IF DESIRED. I ALWAYS RECOMMEND USING THE LOWEST DOSE POSSIBLE
    
    

2) CATEGORY TWO

Patients with a CURRENT BMI of 30-39 (or 27+ with risk factors of high blood pressure, high cholesterol/lipids, or sleep apnea) who have stalled on tirzepatide therapy may qualify as follows to begin Triple G:

• If you have never been on semaglutide or tirzepatide, you would not qualify for Triple G at this time.
  
  
• If you are currently on tirzepatide:
  
  
  • Patients that have stalled on higher doses of tirzepatide may request approval to order Triple G.However, there must not be any recent gaps in your tirzepatide use in order to assess that you have stalled.
  • You must have recently completed at least 4 consecutive weeks of the 7.5mg dose or higher of tirzepatide. If you feel you have stalled and your weight loss had dropped below losing 1-2 pounds a week, you may request approval to order Triple G.
  • If you have not recently completed at least 4 consecutive weeks of the 7.5mg dose or higher, you may not request Triple G until you have done so.Please message us for ordering guidelines.
  • Please use the same ordering guidelines as CATEGORY ONE patients above when choosing the Triple G dose for your first order.
    

• If you are currently on semaglutide:
  • You would switch to tirzepatide before being approved to Order Triple G.
  • You would then follow the above guidelines and request Triple G after stalling on the 7.5mg dose or higher of tirzepatide.
    
    YOU MAY ALSO START AT A LOWER DOSE IF DESIRED. I ALWAYS RECOMMEND USING THE LOWEST DOSE POSSIBLE

PLEASE NOTE: These BMI requirements are starting requirements only, similar to tirzepatide and semaglutide. You will still be eligible for the medication after your BMI falls below the initial criteria when you lose weight from using your medication.

***IF YOUR CURRENT BMI DOES NOT MEET EITHER OF THE ABOVE CRITERIA, YOU ARE NOT ELIGIBLE TO START TRIPLE G AT THIS TIME.***

Current Pricing for each 4-week vial from Striker (5 weeks if halving the dose for the first two weeks as above when first switching over)*:

*Please note that all prices are subject to change at any time. As the Triple G injections becomes more popular, the API sources where compounding pharmacies obtain the source ingredients will likely raise their prices, which in turn raises everyone’s price.

Special thanks to Stephen Smith, PA for the graphic below: